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Discover study

DISCOVER is a medical-scientific study which will research whether a new experimental medicine is safe and effective for use by healthy adults to prevent HIV infections. Preventing an HIV infection prior to being exposed to the risk for HIV is also known as pre-exposure prophylaxis (PrEP). The experimental medicine evaluated in this study is a pill that contains both emtricitabine and tenofovir alafenamide (F/TAF). The target group will be men and transgender women who have sex with men.

Double-blind study

By random allocation, participants will either receive the experimental PrEP medicine F/TAF, or Truvada® (which contains emtricitabine and tenofovir disoproxil fumarate). Both Truvada® and F/TAF have been approved for use by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) as part of chronic HIV treatment. Only Truvada® has been approved for use as PrEP in the United States, Canada and the European Union. The usage of F/TAF for PrEP is investigational and may not be efficacious.
The DISCOVER study was initiated and is financed by the pharmaceutical company GILEAD Sciences, Inc., Foster City, US.

A total of approximately 5000 subjects at about 100 sites in North-America and Europe are participating in this international, medical-scientific study. It is not possible to participate in this study anymore.

More information

For more information regarding this study, you may send an e-mail to Or, you may contact (020) 555 3999 by telephone.